Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.742


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX1chr10_+_1028810500.665.8e-03Click!
TLX3chr5_+_1706688920.224.1e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_40093245 6.501 NM_001145398
TEF
thyrotrophic embryonic factor
chr15_-_38420414 5.768 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr14_+_85066207 5.628 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr17_-_74487527 5.518 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr14_+_85066265 5.459 FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_39180036 5.055 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr21_+_45699830 4.428 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr6_-_30151526 4.423 NM_170769
NM_025236
RNF39

ring finger protein 39

chr21_+_32706615 4.417 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr8_-_22044463 3.765 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr8_-_13178327 3.572


chr19_+_15612706 3.554 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr11_-_85074848 3.477 NM_152723
CCDC89
coiled-coil domain containing 89
chr7_-_16811131 3.451 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr8_-_27524744 3.225 NM_203339
CLU
clusterin
chr8_-_27525084 3.220 NM_001171138
CLU
clusterin
chr1_+_183970093 3.217 NM_031935
HMCN1
hemicentin 1
chr5_+_150000394 3.211 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_-_16217025 3.176 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr14_+_23937766 3.148 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr7_-_27153892 3.122 NM_024014
HOXA6
homeobox A6
chr20_-_5982617 3.118 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr2_-_217268492 3.116 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr1_-_151852128 3.097 NM_080388
S100A16
S100 calcium binding protein A16
chr15_-_38417564 3.094 C15orf52
chromosome 15 open reading frame 52
chr20_+_8997660 3.080 NM_001172646
PLCB4
phospholipase C, beta 4
chr21_-_27139563 3.058 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_+_74542066 3.034 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr20_+_34206070 2.950 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr11_+_74539679 2.950 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr12_+_64504408 2.930 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr21_-_27139143 2.920 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_-_192419896 2.908 SDPR
serum deprivation response
chr16_+_55963899 2.849 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_+_56406296 2.842 LOC100130776
hypothetical LOC100130776
chr2_-_233586164 2.840 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr2_-_233586145 2.834 NGEF
neuronal guanine nucleotide exchange factor
chr2_+_223244606 2.818 NM_058165
MOGAT1
monoacylglycerol O-acyltransferase 1
chr17_+_75507750 2.815


chr12_-_50871953 2.802 NM_001081492
NM_182507
KRT80

keratin 80

chr16_-_49742651 2.763 NM_002968
SALL1
sal-like 1 (Drosophila)
chr20_-_33489383 2.751 NM_000557
GDF5
growth differentiation factor 5
chr2_-_192420168 2.746 NM_004657
SDPR
serum deprivation response
chr19_+_40322231 2.739 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr10_+_685887 2.681 C10orf108
chromosome 10 open reading frame 108
chr20_+_8997791 2.671 PLCB4
phospholipase C, beta 4
chr7_-_99411573 2.660 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr9_+_35663852 2.631 NM_001216
CA9
carbonic anhydrase IX
chrX_-_53327473 2.602 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr6_+_39868770 2.593 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr4_+_86968069 2.526 ARHGAP24
Rho GTPase activating protein 24
chr9_-_78710698 2.512 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr1_+_219026661 2.507 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr17_-_74433048 2.503 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr3_-_12175339 2.481 TIMP4
TIMP metallopeptidase inhibitor 4
chr2_-_228290942 2.478 NM_025243
SLC19A3
solute carrier family 19, member 3
chr9_+_135389698 2.444 NM_014694
ADAMTSL2
ADAMTS-like 2
chr12_-_120781002 2.443 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr1_-_159435440 2.427 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr19_+_3659358 2.426 TJP3
tight junction protein 3 (zona occludens 3)
chr1_-_149611768 2.414 NM_003944
SELENBP1
selenium binding protein 1
chr3_-_11585264 2.409 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr22_-_22970850 2.375 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr2_-_218551786 2.361 TNS1
tensin 1
chr17_+_72795567 2.328 NM_001113492
SEPT9
septin 9
chr20_+_55569542 2.312 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr11_-_56846246 2.309 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr5_+_176449156 2.308 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr1_-_159459814 2.270 APOA2
apolipoprotein A-II
chr1_+_159435728 2.262 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr15_-_66511488 2.261 NM_001004439
ITGA11
integrin, alpha 11
chr9_-_23811842 2.237 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr12_+_99391870 2.229 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr15_-_81412354 2.217 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr9_-_23811808 2.189 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_-_159459999 2.187 NM_001643
APOA2
apolipoprotein A-II
chr14_-_22515725 2.186 JUB
jub, ajuba homolog (Xenopus laevis)
chr14_+_94117545 2.183 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr10_-_100164877 2.172 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr11_-_62213577 2.169 LRRN4CL
LRRN4 C-terminal like
chr12_+_99391681 2.166 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr3_-_198784590 2.149 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr16_+_620932 2.132 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr2_+_233961538 2.126 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr9_+_139241838 2.124 NM_001190228
LOC643596
hypothetical LOC643596
chr17_+_1580504 2.122 WDR81
WD repeat domain 81
chr9_+_130719034 2.108 LRRC8A
leucine rich repeat containing 8 family, member A
chr5_-_148738980 2.096 NM_014443
IL17B
interleukin 17B
chr17_-_74432671 2.082 TIMP2
TIMP metallopeptidase inhibitor 2
chr16_+_2025922 2.029 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr5_+_148941228 2.021 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr16_-_28457825 2.011 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr12_+_123339662 1.952 NM_181709
FAM101A
family with sequence similarity 101, member A
chr17_-_74432800 1.946 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_+_50004134 1.910 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr1_+_61319976 1.905 NM_001145512
NFIA
nuclear factor I/A
chr6_-_138935359 1.898 NM_020464
NHSL1
NHS-like 1
chr9_-_25668855 1.887 NM_001004125
TUSC1
tumor suppressor candidate 1
chr11_-_118716736 1.884 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr19_+_15644885 1.876 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr10_+_135010833 1.856 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr9_-_131555111 1.822 NM_004878
PTGES
prostaglandin E synthase
chr3_+_153499883 1.819 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr19_+_51493486 1.795 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chr4_-_66218777 1.780 EPHA5
EPH receptor A5
chr6_-_112001590 1.776 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr9_+_123083540 1.771 GSN
gelsolin
chr15_-_32875040 1.763 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr19_-_8581559 1.752 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr1_+_213245507 1.745 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chrX_+_46822833 1.740 RGN
regucalcin (senescence marker protein-30)
chr16_-_51139214 1.733 NM_001146188
TOX3
TOX high mobility group box family member 3
chr1_-_32036802 1.680 SPOCD1
SPOC domain containing 1
chr9_-_23811477 1.673 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_+_54132447 1.670 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr5_-_59819642 1.652 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_+_46822751 1.649 RGN
regucalcin (senescence marker protein-30)
chr14_-_21074875 1.645 NM_005407
SALL2
sal-like 2 (Drosophila)
chr6_+_132170888 1.642 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr7_-_123460722 1.632 NM_001136002
TMEM229A
transmembrane protein 229A
chr10_+_88708267 1.627 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr16_-_30032330 1.617 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr11_-_10672079 1.613 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr8_-_143864933 1.605 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr6_+_132170847 1.578 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr5_-_54317102 1.577 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr11_-_62213946 1.575 NM_203422
LRRN4CL
LRRN4 C-terminal like
chrX_+_99785818 1.565 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr22_-_31732648 1.526 NM_003490
NM_133633
SYN3

synapsin III

chr8_-_42184194 1.519 PLAT
plasminogen activator, tissue
chr1_-_32036858 1.504 SPOCD1
SPOC domain containing 1
chr3_+_8750485 1.501 NM_033337
NM_001234
CAV3

caveolin 3

chr17_-_40348378 1.497 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr1_-_245342150 1.490 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr3_-_12175646 1.479 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr7_+_102340579 1.467 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr2_+_242400702 1.456 NM_001167599
NM_001167602
NM_080741
NEU4


sialidase 4


chr17_-_39265965 1.454 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr8_+_22900863 1.436 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chrX_+_46822688 1.433 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr20_+_43468046 1.426 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr2_-_219404755 1.422 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chrX_-_132947290 1.421 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr10_-_105604942 1.401 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr9_-_25668230 1.389 TUSC1
tumor suppressor candidate 1
chr1_-_16411690 1.382 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr18_-_53621277 1.381 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr11_-_2116048 1.375 IGF2
insulin-like growth factor 2 (somatomedin A)
chr10_-_128066935 1.338 ADAM12
ADAM metallopeptidase domain 12
chr17_+_71065478 1.328 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr14_-_75516988 1.318 TGFB3
transforming growth factor, beta 3
chr14_+_94117511 1.316 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr8_-_42184350 1.308 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr8_-_13178399 1.289 DLC1
deleted in liver cancer 1
chr2_+_96818048 1.281 CNNM4
cyclin M4
chr10_-_128067052 1.281 ADAM12
ADAM metallopeptidase domain 12
chr1_-_151855413 1.279 NM_020672
S100A14
S100 calcium binding protein A14
chr12_+_118100977 1.268 NM_014365
HSPB8
heat shock 22kDa protein 8
chr1_+_175407153 1.261 NM_021165
FAM5B
family with sequence similarity 5, member B
chr19_-_38408449 1.249 NM_019849
SLC7A10
solute carrier family 7, (neutral amino acid transporter, y+ system) member 10
chr9_-_8723893 1.239 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr17_-_24972471 1.230 NM_032854
CORO6
coronin 6
chr1_+_1836125 1.229 NM_138705
CALML6
calmodulin-like 6
chr5_+_135293889 1.229 NM_012159
FBXL21
F-box and leucine-rich repeat protein 21 (gene/pseudogene)
chr9_-_112010233 1.211 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr6_-_3390197 1.202 NM_021945
SLC22A23
solute carrier family 22, member 23
chr20_+_19815075 1.185 RIN2
Ras and Rab interactor 2
chr9_-_123302126 1.184 GGTA1
glycoprotein, alpha-galactosyltransferase 1 pseudogene
chr11_-_10671873 1.183 MRVI1
murine retrovirus integration site 1 homolog
chrX_-_132947141 1.183 GPC3
glypican 3
chr17_-_72045218 1.179 NM_134268
CYGB
cytoglobin
chr3_+_38007264 1.176 VILL
villin-like
chr1_-_151804929 1.171 NM_005978
S100A2
S100 calcium binding protein A2
chr20_+_19903778 1.162 RIN2
Ras and Rab interactor 2
chr12_-_54392328 1.161 NM_001144997
ITGA7
integrin, alpha 7
chr17_+_24394281 1.158 PIPOX
pipecolic acid oxidase
chr9_-_135594715 1.148 NM_007101
SARDH
sarcosine dehydrogenase
chr7_+_1094248 1.145 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr16_+_56219802 1.139 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr17_-_77394872 1.128 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr11_-_10671736 1.128 MRVI1
murine retrovirus integration site 1 homolog
chr14_-_75517076 1.121 TGFB3
transforming growth factor, beta 3
chrX_-_54539043 1.110 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr17_-_44226595 1.109 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr22_-_29866339 1.104 NM_015715
PLA2G3
phospholipase A2, group III
chr8_+_120497732 1.101 NM_002514
NOV
nephroblastoma overexpressed gene
chr5_+_66160359 1.098 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr20_+_33223434 1.089 NM_006404
PROCR
protein C receptor, endothelial
chr1_+_1207351 1.082 NM_001130413
NM_002978
SCNN1D

sodium channel, nonvoltage-gated 1, delta

chr3_-_197103848 1.074 TNK2
tyrosine kinase, non-receptor, 2
chr11_+_128266460 1.068 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr14_+_94117483 1.066 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_+_71232370 1.062 NM_001005619
ITGB4
integrin, beta 4
chr9_-_123301856 1.056 GGTA1
glycoprotein, alpha-galactosyltransferase 1 pseudogene
chr10_-_128067001 1.056 ADAM12
ADAM metallopeptidase domain 12
chr14_+_69021149 1.027 NM_001161498
UPF0639
UPF0639 protein
chrX_+_153423652 1.020 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr21_+_36993302 1.018


chr20_-_60360789 1.016 LAMA5
laminin, alpha 5
chr19_-_40696393 1.012 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine







Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.03 3.50e-02 GO:0090066 regulation of anatomical structure size

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.64 5.14e-04 GO:0044421 extracellular region part
1.43 6.44e-04 GO:0005576 extracellular region
1.93 1.81e-02 GO:0031012 extracellular matrix

Nothing significant found in function category.